The player assumes the role of a driver in Zombie Arena 2 Fury Road, whose objective is to navigate a confined arena populated by zombies while using their vehicle as a weapon to overcome waves of the undead and unlock new levels. Also, there are modes where you have to beat the clock or fend off waves of zombies, respectively, and games where you have to live as long as possible.

In the main campaign, you'll have to complete a number of objectives where you have to do things like wipe out zombies from the battlefield and demolish regions that are filled with zombies.